Percutaneous gel preparation
AssigneesNitto Denko Corporation, Toa Eiyo Ltd.
InventorsHitoshi Akemi, Saburo Otsuka, Takashi Kinoshita, Yoshifumi Hosaka, Yoshihisa Nakano
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Abstract
A percutaneous gel preparation is disclosed, which comprises a substrate having one surface thereof a crosslinked gel layer formed by crosslinking a composition comprising the following ingredients (a) to (c), the weight ratio of the ingredient (b) to the ingredient (c) being from 1.0/0.25 to 1.0/2.0: (a) isosorbide dinitrate; (b) an acrylate polymer; and (c) a liquid ingredient compatible with the ingredient (b).
Claims10
A percutaneous gel preparation comprising a substrate having on one surface thereof a crosslinked gel layer formed by crosslinking a composition comprising the following ingredients (a) to (c), the weight ratio of said ingredient (b) to said ingredient (c) being from 1.0/0.25 to 1.0/2.0:
- (a) isosorbide dinitrate;
- (b) an acrylate polymer obtained by polymerizing alkyl (meth)acrylates used in the production of adhesives;
- and
- (c) a non-aqueous liquid ingredient compatible with said ingredient (b), wherein said ingredient (c) is selected from the group consisting of phthalic acid esters, isopropyl myristate, isotridecyl myristate, and octyl palmitate.
A process for producing a percutaneous gel preparation, comprising the following steps:
- (1) providing a composition comprising the following ingredients (a) to (c), the weight ratio of said ingredient (b) to said ingredient (c) being from 1.0/0.25 to 1.0/2.0:
- (a) isosorbide dinitrate;
- (b) an acrylate polymer obtained by polymerizing alkyl (meth)acrylates;
- and
- (c) a non-aqueous liquid ingredient compatible with said ingredient (b), wherein said ingredient (c) is selected from the group consisting of phthalic acid esters, isopropyl myristate, isotridecyl myristate, and octyl palmitate;
- (2) crosslinking the composition of said step (1) to produce a gel layer;
- and
- (3) applying said gel layer to a substrate.
Dependencies are inferred from the claim text.