Slow-releasing composition of platinum-containing anticancer agent
AssigneeUnitika Ltd.
InventorsRyoichi Tsurutani, Koji Kifune, Yuriko Nakamura
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Abstract
A slow-releasing composition of a platinum-containing anticancer agent comprising a platinum-containing anticancer agent bound to deacetylated chitin. The release of the platinum-containing anticancer agent is sustained for a prolonged duration of several months, thereby minimizing undesirable side effects of the platinum-containing anticancer agent.
Claims13
A pharmaceutical composition consisting essentially of a platinum-containing anticancer agent bound to deacetylated chitin and a pharmaceutically acceptable carrier, wherein the composition has a slow-release property over a duration of at least four months.
A method for preparing a pharmaceutical composition having a slow-release property over a duration of at least four months and consisting essentially of a platinum-containing anticancer agent bound to deacetylated chitin and a pharmaceutically acceptable carrier, comprising
- (A) contacting a solution of said dissolved platinum-containing anticancer agent with deacetylated chitin;
- (B) recovering said platinum-containing anticancer agent bound to deacetylated chitin;
- and
- (C) adding the pharmaceutically acceptable carrier to obtain said pharmaceutical composition,
- wherein said composition does not release said anticancer agent in a saline solution or an aqueous acid solution and wherein said composition releases said anticancer agent in the presence of a lysozyme.
Dependencies are inferred from the claim text.