Process for restoring an osseous defect or deficiency by filling with osseous tissue
AssigneeS.A. FBFC International
InventorsEvert Schepers, Paul Ducheyne, Raymond Kempeneers
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Abstract
Process for the restoration of an osseous defect or deficiency by filling with osseous tissue with the aid of a bioreactive granular material causing an osteostimulation, the particles of said granular material being disintegrated from the inside, dissolved and replaced by osseous tissue, the granular material containing 40 to 55% SiO.sub.2, 10 to 32% Na.sub.2 O, 0 to 12% P.sub.2 O.sub.5 and 10 to 32% CaO, which has a grain size distribution between 280 and 425 .mu.m, sharp edges, an irregular profile and surface microdefects or microcracks.
Claims8
Process for the formation of osseous tissue for filling an osseous defect or deficiency, comprising introducing particles consisting essentially of an inorganic, non-fluorinated, bioreactive granular material having sharp edges, an irregular profile and surface defects or microcracks into said osseous defect or deficiency in order to cause osteogenesis by osteostimulation, said particles being progressively dissolved internally, by way of said surface defects or microcracks to create a central cavity in which mesenchymal precursor cells are differentiated into osteoblasts, followed by progressive replacement of said particles by osseous tissue,
- said particles consisting essentially of, by weight:
- SiO.sub.2 between 40 and 55%;
- Na.sub.2 O between 10 and 32%;
- P.sub.2 O.sub.5 between 0 and 12%;
- and
- CaO between 10 and 32%;
- and having a grain size distribution such that at least 95% of the particles are between 280 and 425 .mu.m.
Dependencies are inferred from the claim text.