Shiga toxin B chain polypeptides and vaccine thereto
AssigneeYeda Research and Development Co. Ltd.
InventorsRuth Arnon, Ilana Harari, Gerald T. Keusch, Arthur Donohue-Rolfe
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Abstract
The invention relates to a number of synthetic polypeptides which correspond to a part of the sequences of the Shiga B peptide chain. More specifically, the invention relates to polypeptides corresponding to the residues 5 to 18, 7 to 26, 13 to 26, and 19 to 29 of said B chain. The invention further relates to the conjugates of each of these with a suitable carrier and to polymers of each or these obtained by polymerization with a suitable polymerization agent: these can be used as effective vaccines which afford protection against Shiga toxin. Anti-peptide anti-sera are effective in neutralizing to a large extent the biological activity of Shiga toxin.
Claims8
A peptide corresponding to a sequence of residues of the Shiga toxin B chain, the sequence consisting essentially of residues 5 to 18, 7 to 26, 13 to 26 or 19 to 29 of the Shiga toxin B chain, conjugated to suitable carrier.
A peptide corresponding to a sequence of residues of the Shiga toxin B chain, the sequence consisting essentially of residues 5-18, 7-26, 13-26 or 19-29 of the Shiga toxin B chain in polymeric form obtained by polymerization or interpolymerization of said residues with a suitable polymerization agent.
Dependencies are inferred from the claim text.