Loading patent…
AssigneeMallinckrodt Inc.
InventorsNarciso O. Doran, III, Thomas J. Dunn, Mills T. Kneller, Youlin Lin, David H. White, David Ming-Lee Wong
Estimating the term…
An improved process for the reversed phase chromatographic decolorization, separation, and purification of water-soluble, nonionic contrast media compounds from solutions containing nonionic compound impurities involves the steps of (a) packing a chromatographic column with a chromatographic packing material; (b) passing through the column a solution containing a water-soluble, nonionic contrast media compound and nonionic compounds as impurities at a loading ratio between approximately 10 to 1 and 1.5 to 1 wt. packing material/total wt. nonionic compounds; and (c) eluting the column to produce an eluate containing substantially pure, water-soluble, nonionic contrast media compound or MRI agent. The process can be economically practiced on a factory scale and efficiently removes non-polar impurities difficult to remove by conventional methods.
A process for the reversed phase chromatographic decolorization, separation, and purification of water-soluble, nonionic contrast media compounds from solutions containing nonionic compound impurities, said solutions having been treated for removal of ionic impurities;
A process for the separation and purification of the nonionic X-ray contrast media compound N,N'-bis(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl)glycolamido]-2,4,6-trii odoisophthalamide from solutions containing nonionic compound impurities including 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triodoisophthalamide and N,N'-bis (2,3-dihydroxypropyl)-5-[[N(2-hydroxyethyl)-carbamoyl]methoxy] -2,4,6-trii odoisophthalamide comprising the steps of:
Dependencies are inferred from the claim text.