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US 5,202,486 AGranted
Tetrahydroethanonaphthaleneamine derivatives
AssigneeE. R. Squibb & Sons, Inc.
InventorsJoel C. Barrish, Steven H. Spergel
Life of this patent
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Abstract
Tetrahydronaphthaleneamine derivatives having the formula ##STR1## wherein R, R', R.sub.1 and R.sub.2 are as defined herein, are novel calcium channel blockers.
Claims8
A compound having the general formula ##STR41## including pharmaceutically acceptable slats thereof, wherein one of R and R' is hydrogen and the other is ##STR42## R.sub.1 is hydrogen, halogen, alkyl, haloalkyl, hydroxy, alkoxy, aryl, arylalkoxy, arylalkyl, fluorosubstituted alkyl;
- R.sub.2 is hydrogen, halogen, alkyl, alkoxy, arloxy, arylalkoxy, arylalkyl, hydroxy, ##STR43## fluoro substituted alkoxy, fluoro substituted alkyl, (cycloalkyl)alkoxy, --NO.sub.2, --NY.sub.3 Y.sub.4,
- n is 0, 1, 2 or 3;
- q and r are independently 0, 1, 2, or 3, with the proviso that one of q and r must be other than zero;
- R.sub.3 and R.sub.4 are each independently hydrogen, alkyl, cycloalkyl or arylalkyl;
- Y.sub.1 and Y.sub.2 are each independently hydrogen, alkyl or aryl;
- Y.sub.3 and Y.sub.4 are each independetly hydrogen, or alkyl,
3 more elements
Dependencies are inferred from the claim text.