Anchimeric radiometal chelating compounds
AssigneeNeoRx Corporation
InventorsAlan R. Fritzberg, Ananthachari Srinivasan
Life of this patent
Estimating the term…
Abstract
Anchimeric chelates are disclosed which are capable of rapidly forming stable chelates with radionuclide metals at or below physiological temperature. Bifunctional anchimeric chelates having these same properties are also disclosed which are useful for radiolabeling target specific molecules such as monoclonal antibodies and fragments thereof.
Claims22
A chelating compound comprising a first site at which a complex of a radionuclide metal forms, a second site at which a chelate of the radionuclide metal forms, and a conjugation group capable of reacting with a protein to bind the chelating compound to the protein, wherein said first site comprises two or more atoms selected from oxygen, nitrogen and phosphorous, said second site comprises a heteroatom chain containing at least one sulfur atom and at least two nitrogen atoms, and said complex formed at said first site has a faster rate of formation and a lower thermodynamic stability than said chelate formed at said second site, such that when the radionuclide metal is combined with said compound, the complex at the first site forms initially, and the radionuclide metal subsequently is transferred to the second site to form the chelate.
Dependencies are inferred from the claim text.