Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use

A glycopolypeptide multimer composition produced according to the method comprising:

• (a) introducing into the genome of a first member of a plant species a first mammalian gene coding for an autogenously linking immunoglobulin heavy chain monomeric polypeptide having an N-linked glycosylation signal, to produce a first trnasformant;
• (b) introducing into the genome of a second member of said plant species a second mammalian gene coding for an autogenously linking immunoglobulin light chain monomeric polypeptide, to produce a second transformant;
• (c) generating from said first and second transformants a progeny population;
• (d) isolating from said progeny population a transgenic plant species that produces an immunologically active glycopolypeptide multimer;
• and
• (e) recovering from said transgenic plant species a composition comprising said glycopolypeptide multimer and plant material.