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US 5,198,583 AGranted
Optically active cyclobutane nucleoside and intermediates, therefor
AssigneeE. R. Squibb & Sons, Inc.
InventorsGregory S. Bisacchi, Toomas Mitt
Life of this patent
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Abstract
The optically active antiviral compound [1R-(1.alpha., 2.beta., 3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)-cyclobutyl]-1,9-dihydro-6H-pu rin-6-one and novel intermediates useful in its preparation are described.
Claims4
A compound having the formula ##STR4## wherein R.sup.1 is straight or branched chain lower alkyl of 1 to 5 carbons,
- R.sup.3 is a chiral straight or branched chain alkyl of up to 10 carbons, a chiral substituted alkyl of up to 10 carbons wherein said substitutents are selected from the group consisting of hydroxy, lower alkoxy of 1 to 5 carbons, lower alkoxycarbonyl of 2 to 6 carbons, phenyl, hydroxyphenyl, dihydroxyphenyl, nitrophenyl, and naphthyl, ##STR5## or a chiral moiety of the formula ##STR6## wherein R is straight or branched chain lower alkyl of 1 to 5 carbons.
Dependencies are inferred from the claim text.