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US 5,198,421 AGranted
Phosphorylated cyclic lipopeptide
AssigneeMerck & Co., Inc.
InventorsShieh-Shung T. Chen, David J. Mathre, Brian R. Petuch, Robert A. Reamer
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Abstract
There is disclosed a monophosphorylated cyclic lipopeptide compound obtained by biophosphorylating a cyclic lipopeptide related to echinocandins and having a peptide skeleton bearing several hydroxy groups wherein in the phosphorylated cyclic lipopeptide, the phosphate group is attached to the hydroxy group of the 4-hydroxyproline component of the lipopeptide. The compounds are useful for the control of fungi and parasites.
Claims6
A phosphorylated cyclic lipopeptide compound having the formula SEQ ID NO:
- 1:
- ##STR8## wherein R is ##STR9## or a cation salt thereof.
Dependencies are inferred from the claim text.