US 5,198,109 A · Diffusion cell

Abstract

A diffusion cell to facilitate the automated removal of test aliquots of liquid from a receptor chamber of the diffusion cell so as to determine percutanous absorption through a membrane of a donor fluid from a donor chamber into the receptor chamber of the diffusion cell. There is utilized a sampling port through which the test aliquot is to be removed, the removal being achieved by means of a sample tube which is to be movable into and out of the receptor chamber. Within the receptor chamber is located a stirring device in the form of a helical coil which is to be rotated to achieve stirring and homogeneous mixing of the liquid within the receptor chamber. A refilling tube connects also with the receptor chamber to add liquid into the receptor chamber as the test aliquot has been removed. A leveling tube within the sampling port is to restore the initial preset receptor liquid volume between sampling intervals.

Claims8

Dependent claims

A diffusion cell comprising:

a chamber divided by a membrane into a donor chamber and a receptor chamber, a liquid filling said receptor chamber and being in contact with said membrane, a media to be supplied into said donor chamber with said media being permitted to diffuse through said membrane and mixed with said liquid;
a sample port connecting with said receptor chamber, said sample port permitting removal of a quantity of said liquid;
a refilling port connecting with said receptor chamber, said refilling port permitting supplying of an additional quantity of said liquid into said receptor chamber;
and
said receptor chamber including a mixing device, said mixing device to be operated to effect even mixing of said liquid within said receptor chamber, said mixing device comprising a helical coil of a length equal to at least one half the length of said receptor chamber.

2 more elements

Dependencies are inferred from the claim text.

Diffusion cell

Life of this patent

Diffusion cell

Life of this patent

Abstract

Claims8