Process for producing alcohol or amine
AssigneeKao Corporation
InventorsTomohito Kitsuki, Yoshiaki Fujikura
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Abstract
Disclosed herein is a process for producing an alcohol or an amine by reducing a compound having a formyl, keto, nitro, oxirane, ester, nitrile, amide or halogenated carboxyl group with an alkali metal boro-hydride in the presence of a compound having a hydroxyl group and ether linkage. According to the present invention, a functional group having a great steric hindrance can be reduced, and a corresponding alcohol or amine can efficiently be produced under very mild conditions on an industrial scale.
Claims5
A process for producing an alcohol or an amine, which comprises reducing a compound having a formyl, keto, nitro, oxirane, ester, nitrile, amide, carboxyl or halogenated carboxyl group with an alkali metal borohydride in the presence of a compound having a hydroxyl group and ether linkage, wherein the compound having a hydroxyl group and ether linkage is a compound represented by formula (I):
- ##STR4## wherein R.sup.1 represents an alkyl group or an alkenyl group;
- R.sup.2 represents a hydrogen atom or an alkyl group;
- R.sup.1 and R.sup.2 may be linked together to form an alkylene group;
- and m represents a number of 1 to 5.
A process for producing bornane-3-spiro-1'-cyclopentane-2-ol which is represented by formula (III), ##STR5## which process comprises reducing bornane-3-spiro-1'-cyclopentane-2-one represented by formula (II):
- ##STR6## with an alkali metal boro-hydride in the presence of a compound having a hydroxyl group and ether linkage.
Dependencies are inferred from the claim text.