Ultrasonic manometry process in a fluid by means of microbubbles
AssigneeSchering Corporation
InventorsReinhard Schlief, Hans Poland
Life of this patent
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Abstract
The invention relates to an ultrasonic manometry process in a fluid containing stabilized micro bubbles in an ensemble, wherein ultrasonic impulses are radiated into the fluid and brought to interact with the micro bubbles. The amplitude and/or frequency alterations in the ultrasonic scatter signals are recorded and evaluated compared with the ultrasonic impulses radiated in and/or previously recieved. Preparations for measuring blood pressure which can be used with the manometry process are described.
Claims33
An ultrasonic manometry process in a fluid comprising introducing microbubbles into a fluid, radiating ultrasonic impulses into the fluid, and receiving and evaluating ultrasonic impulses after interaction of the radiated ultrasonic impulses with the microbubbles to determine fluid pressure, wherein the frequency range of ultrasonic impulses which are received and evaluated lie outside of the frequency range of the ultrasonic impulses radiated into the fluid and wherein the microbubbles are those created by introducing into the fluid an ensemble comprising the microbubbles and microparticles of a mixture of a semi-solid or fluid boundary surface active substance with a non-boundary surface active solid in a fluid carrier.
A process according to 7, wherein the ensemble contains as the fluid carrier which is physiologically compatible water, physiological electrolyte solution, an aqueous solution of single or multi-valent alcohols or the aqueous solution of a mono- or disaccharide.
An ultrasonic manometry process in a fluid comprising introducing microbubbles into a fluid, radiating ultrasonic impulses into the fluid, and receiving and evaluating ultrasonic impulses after interaction of the radiated ultrasonic impulses with the microbubbles to determine fluid pressure, wherein the frequency range of ultrasonic impulses which are received and evaluated lie outside of the frequency range of the ultrasonic impulses radiated into the fluid and wherein the microbubbles are those created by introducing into the fluid an ensemble comprising the microbubbles and microparticles of a solid boundary surface active substance in combination with microparticles of a non-boundary surface active solid in a fluid carrier.
An ultrasonic manometry process in a fluid comprising introducing microbubbles into a fluid, radiating ultrasonic impulses into the fluid, and receiving and evaluating ultrasonic impulses after interaction of the radiated ultrasonic impulses with the microbubbles to determine fluid pressure, wherein the frequency range of ultrasonic impulses which are received and evaluated lie outside of the frequency range of the ultrasonic impulses radiated into the fluid and wherein the microbubbles are those created by introducing into the fluid an ensemble comprising a fluid mixture for absorbing and stabilizing gas bubbles filled with physiologically compatible gas, comprising the mixture of 0.01% to 10% of a tenside or tenside mixture with an aqueous carrier fluid or one miscible with water and the mixture of 0.5% to 50% of a viscosity-increasing substance or a substance mixture in an aqueous carrier fluid or carrier fluid miscible with water.
Dependencies are inferred from the claim text.