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US 5,194,581 AGranted
Biodegradable poly(phosphoesters)
OwnerKam W. Leonginventor
Life of this patent
Estimating the term…
Abstract
The invention relates to poly(phosphoesters), compositions comprising the poly(phosphoesters), and methods of use.
Claims6
A polymer represented by the formula:
- ##STR22## wherein n ranges from about 10 to about 10.sup.5, R is a therapeutic agent capable of being released in a physiological environment, and R' is selected from the group consisting of:
- ##STR23## wherein R.sub.1 is alkyl, halogen, nitro, hydroxyl, amino, carboxyl, alkoxy, or combinations thereof, R.sub.2 is oxygen or N--CH.sub.3 and a ranges from 2 to 6, b ranges from 10 to 100, d ranges from 2 to 16, f ranges form 1 to 6, and m ranges from 1 to 2.
A polymer represented by the formula:
- ##STR24## wherein n ranges from about 10 to about 10.sup.5, R' is a therapeutic agent capable of being released in a physiological environment, and R is selected form the group consisting of:
- ##STR25## wherein R.sub.1 is alkyl, halogen, nitro, hydroxyl, amino carboxyl, alkoxy, or combinations thereof, R.sub.3 is ##STR26## and p ranges from 1 to 16.
A polymer represented by the formula:
- ##STR27## wherein n=10 to 10.sup.5, and both R and R' are therapeutic agents capable of being released in a physiological environment.
A polymer represented by the formula:
- ##STR28## wherein n ranges from about 10 to about 10.sup.5, R' is selected from the group consisting of:
- ##STR29## R is selected from the group consisting of:
- ##STR30## wherein R, is alkyl, halogen, nitro, hydroxyl, amino, carboxyl, alkoxy, or combinations thereof, R.sub.2 is oxygen or N--CH.sub.3, ##STR31## A ranges from 2 to 6, B ranges from 10 to 100, D ranges from 2 to 16, F ranges from 1 to 6, M ranges from 1 to 2, and P ranges from 1 to 16.
Dependencies are inferred from the claim text.