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AssigneesOtsuka Pharmaceutical Co., Ltd., Otsuka Pharmaceutical Factory, Inc.
InventorsYoshihisa Takaishi, Kiyoto Goto, Takuji Uesako, Toshiko Kuwahara, Masaaki Takai, Yukihisa Ono, Yoshihiro Taniguchi, Sachiko Manabe, Takahiro Asakuni
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Novel phenanthrene derivatives represented by the general formula (1), ##STR1## wherein the group of the formula ##STR2## is a group of the formula ##STR3## (wherein R.sup.1 is a hydrogen atom or a lower alkyl group), a group of the formula ##STR4## (wherein R.sup.2 is a hydrogen atom or a lower alkanoyl group) or a group of the formula ##STR5## (wherein R.sup.2 is the same as defined above), and salts thereof, and other compounds derived therefrom and salts thereof; processes for preparing the same; and interleukin-1 (IL-1) inhibitors containing the abovementioned novel phenanthrene derivatives as to the active ingredient(s).
A phenanthrene derivative selected from the group consisting of compounds represented by the general formula (1), ##STR25## wherein the group of the formula ##STR26## is a group of the formula ##STR27## wherein R.sup.1 is a hydrogen atom or a lower alkyl group, a group of the formula ##STR28## wherein R.sup.2 is a hydrogen atom or a lower alkanoyl group, a group of the formula ##STR29## wherein R.sup.2 is the same as defined above, a group of the formula ##STR30## a compound of the formula (2), ##STR31## a compound of the formula (3), ##STR32## compounds represented by the general formula (4), ##STR33## wherein R.sup.3 is a hydrogen atom or a methyl group, a compound of the general formula (7), ##STR34## compounds represented by the general formula (8), ##STR35## wherein R.sup.2 is the same as defined above and R.sup.4 is a lower alkanoyloxy group,
3,4,4a,5,8, 9,10,10a-Ocathydro-1,4-a-dimethyl-7-(1-methylethyl)-5,8-dioxo-2-phenanthren ecarboxylic acid.
5,6,8,8a,9,10- Hexahydro-8-hydroxymethyl-4b,8-dimethyl-2-(1-methylethyl)-1,4,7(4bH)-phenan threnetrione.
Dependencies are inferred from the claim text.