Cyclic cell adhesion modulation compounds

A compound of the formula ##STR54## and pharmaceutically acceptable salts thereof, wherein L.sup.1 and L.sup.2 are each, or are together, a residue of an amino acid, an amino acid analog or an amino acid mimetic having a functional group suitable for the formation of a cyclizing bridge between L.sup.1 and L.sup.2 ;

• Z is a cyclizing moiety or bond between L.sup.1 and L.sup.2 ;
• 1is optional and, where present, is selected from the group consisting of Leu, Sar, D-Nal, Tyr, Phe, Ile, Pro, Gly, Ala, Val, norLeu, norVal, .beta.-Ala, Trp, and (Ada -Ala;
• 2 is selected from the group consisting of Arg, homoArg and norArg.
• 4 is selected from Asp and, where 2 is norArg, Glu.
• 5 is optional and, where present, is selected from the group consisting of Ser, Thr, Tyr, Trp, Ala, Val, Phe ##STR55## wherein m is 2, 3 or 4;
• 6is optional and, where present, is selected from the group consisting Pro, 3-thioPro, 1,1-ACC, Dhp, Hyp, homoPro and Phe;
• X.sup.1 and Y.sup.1 are each optional and, where present, are independently selected from sequences of 1 to 4 D- or L-amino acids or amino acid analogs;
• X.sup.2 is an optional N.sup..alpha. -substituent selected from R'-(including hydrogen) and R'CO--;
• and
• Y.sup.2 is an optional carboxyl terminal substituent selected from the group consisting of --OR' (including hydroxy), --NR'.sub.2 (including --NH.sub.2 and --NHR'), --NHNH.sub.2 and --SR';
• and wherein each R' is individually a pharmaceutically suitable substituent group, preferably one selected from the group consisting of hydrogen, linear and branched, unsubstituted and substituted C.sub.1 -C.sub.8 lower alkyls, C.sub.2 -C.sub.8 alkenyls, C.sub.2 -C.sub.8 alkenyls, C.sub.2 -C.sub.8 alkynyls, C.sub.6 -C.sub.14 aryls, C.sub.7 -C.sub.14 alkaryls, C.sub.7 -C.sub.14 alkaryls and C.sub.3 -C.sub.14 cycloalkyls, and, in the case of --NR'.sub.2, from cyclized groups forming (in an attachment with the nitrogen atom) a 5-8 membered heterocyclic ring optionally containing oxygen, nitrogen or sulfur as a further ring heteroatom.