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AssigneeBiocyte Corporation
InventorsEdward A. Boyse, Hal E. Broxmeyer, Gordon W. Douglas
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The present invention relates to hematopoietic stem and progenitor cells of neonatal or fetal blood that are cryopreserved, and the therapeutic uses of such stem and progenitor cells upon thawing. In particular, the present invention relates to the therapeutic use of fetal or neonatal stem cells for hematopoietic (or immune) reconstitution. Hematopoietic reconstitution with the cells of the invention can be valuable in the treatment or prevention of various diseases and disorders such as anemias, malignancies, autoimmune disorders, and various immune dysfunctions and deficiencies. In another embodiment, fetal or neonatal hematopoietic stem and progenitor cells which contain a heterologous gene sequence can be used for hematopoietic reconstitution in gene therapy. In a preferred embodiment of he invention, neonatal or fetal blood cells that have been cryopreserved and thawed can be used for utologous (self) reconstitution.
A method for obtaining human neonatal for fetal hematopoietic stem or progenitor cells comprising:
A method for hematopoietic or immune reconstitution of a human comprising:
A method for hematopoietic or immune reconstitution of a human comprising:
A method for obtaining cryopreserved human neonatal or fetal hematopoietic stem cells derived from the blood comprising:
A method for hematopoietic or immune reconstitution of a human comprising introducing into the human a composition comprising human neonatal or fetal hematopoietic stem cells derived from the blood, in which the stem cells have been previously cryopreserved.
A method for hematopoietic or immune reconstitution of a human comprising introducing into the human a composition comprising human neonatal or fetal hematopoietic stem cells derived from the blood, in which the stem cells are progeny of cells which have been previously cryopreserved.
Dependencies are inferred from the claim text.