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US 5,192,539 AGranted
Infectious bursal disease virus production in continuous cell lines
AssigneeAkzo N.V.
InventorsPiet Van Der Marel, Pieter G. Mooren
Life of this patent
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Abstract
Infectious bursal disease virus vaccine free of avian cell material comprising inactivated virus or live virus that induces a protective immune response when administered to poultry by noninjection means.
Claims11
A line infectious bursal disease virus (IBDV) vaccine free of avian cell material comprising IBDV derived from a mammalian cell line infected with IBDV, wherein said vaccine induces a protective immune response when administered to poultry in a medium selected from the group consisting of eye drops, nose drops, drinking water and sprays.
A method for the preparation of live IBDV vaccine comprising:
- (a) culturing IBDV in a mammalian cell line,
- (b) harvesting live virus from the cultured cell line, and
- (c) subjecting the harvested live virus to at least one of the following treatments:
- i. adding a pharmaceutically acceptable carrier or diluent,
- ii. adding adjuvant,
- iii. lyophilizing,
- the live vaccine is effective in inducing a protective immune response when administering to poultry in a medium selected from the group consisting of eye drops, nose drops, drinking water and sprays.
4 more elements
Dependencies are inferred from the claim text.