Artificial lung and method of using it
AssigneesDainippon Ink and Chemicals, Inc., Kuraray Co., Ltd.
InventorsTakanori Anazawa, Kazutaka Murata, Hiroyuki Akasu, Rishichi Mimura
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Abstract
A membrane-type artificial lung adapted to perform exchange of gases between blood and a gas through a membrane by passing blood over one side of the membrane and oxygen or an oxygen-containing gas over the other side, said membrane being a hollow fiber membrane which is composed mainly of a polyolefin, has an inside diameter of 10 to 500 micrometers, a thickness of 5 to 100 micrometers, a porosity of 7 to 50% and an oxygen flux, Q(O.sub.2), of at least 1.times.10.sup.-6 [cm.sup.3 (STP)/(cm.sup.2.sec.cmHg)] and is substantially impermeable to ethanol.
Claims8
A hollow fiber artificial lung adapted to perform exchange of gases between blood and a gas through a hollow fiber membrane by passing blood over one side of the membrane and oxygen or an oxygen-containing gas over the other side, said hollow fiber membrane consisting essentially of a polyolefin, said hollow fiber membrane having:
- an inside diameter of 10 to 500 micrometers;
- a thickness of 5 to 100 micrometers;
- a porosity of 7 to 50%,
- an oxygen flux, Q(O.sub.2), of at least 1.times.10.sup.-6,
- a barrier layer having an average thickness of not more than 2 micrometers as calculated from oxygen flux Q(O.sub.2) and nitrogen flux Q(N.sub.2), and
- an ethanol flux across the hollow fiber membrane of not more than 30 ml/(min.m.sup.2).
A method of exchanging gases between blood and an oxygen-containing gas comprising:
- providing a hollow fiber artificial lung adapted to perform exchange of gases between blood and a gas through a hollow fiber membrane by passing blood over one side of the membrane and oxygen or an oxygen-containing gas over the other side, said hollow fiber membrane consisting essentially of a polyolefin, said hollow fiber membrane having:
- an inside diameter of 10 to 500 micrometers;
- a thickness of 5 to 100 micrometers;
- a porosity of 7 to 50%,
- an oxygen flux, Q(O.sub.2), of at least 1.times.10.sup.-6, and
- a barrier layer having an average thickness of not more than 2 micrometers as calculated from oxygen flux Q(O.sub.2) and nitrogen flux Q(N.sub.2) which is substantially impermeable to ethanol;
- and
- passing an oxygen-containing gas over an inside surface of the membrane and blood over an outside surface, thereby performing exchange of gases between said blood and said oxygen-containing gas.
A method of exchanging gases between blood and an oxygen-containing gas comprising:
- providing a hollow fiber artificial lung adapted to perform exchange of gases between blood and a gas through a hollow fiber membrane by passing blood over one side of the membrane and oxygen or an oxygen-containing gas over the other side, said hollow fiber membrane consisting essentially of a polyolefin, said hollow fiber membrane having:
- an inside diameter of 10 to 500 micrometers;
- a thickness of 5 to 100 micrometers;
- a porosity of 7 to 50%,
- an oxygen flux, Q(O.sub.2), of at least 1.times.10.sup.-6, and
- a barrier layer having an average thickness of not more than 2 micrometers as calculated from oxygen flux Q(O.sub.2) and nitrogen flux Q(N.sub.2) which is substantially impermeable to ethanol;
- and
- passing an oxygen-containing gas over an outside surface of the membrane and blood over an inside surface, thereby performing exchange of gases between said blood and said oxygen-containing gas.
Dependencies are inferred from the claim text.