Treated tissue for implantation and methods of treatment and use
AssigneeColorado State University Research Foundation
InventorE. Christopher Orton
Life of this patent
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Abstract
Tissue which is suitable for transplant is treated with a growth factor and cells which populate the tissue and native cells must be removed, they cannot be "masked" reduce immunogenicity; this increases the longevity of the tissue upon transplant. The preferred growth factor is basic fibroblast growth factor, and the preferred cells are fibroblasts. The tissue can be an allograft or xenograft taken from a cow, pig or other mammal.
Claims24
An implantable human heart valve treated with growth factor effective on fibroblast cells and populated with fibroblast cells in an amount and for a time period effective for rendering the heart valve substantially non-immunogenic upon implant into a mammal.
An implantable non-human mammalian heart valve treated with growth factor effective on fibroblast cells and populated with fibroblast cells in an amount and for a time period effective for rendering the heart valve substantially non-immunogenic upon implant into a mammal.
A method of reducing the immunogenicity or improving the longevity of an implantable mammalian heart valve comprising:
- treating the heart valve with growth factor effective on fibroblast cells, and
- populating the heart valve with fibroblasts in an amount effective for reducing the immunogenicity of the heart valve upon implant into a patient.
A method of reducing transplant tissue rejection of an implantable mammalian heart valve comprising:
- treating the heart valve with growth factor effective on fibroblast cells, and
- populating the treated heart valve with fibroblasts to reduce tissue rejection upon transplant into a patient.
Dependencies are inferred from the claim text.