System for monitoring and controlling blood glucose
OwnerYoram Paltiinventor
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Abstract
Systems are disclosed which utilize implanted glucose sensitive living cells to monitor blood glucose levels. The implanted cells produce a detectable electrical or optical signal in response to changes in glucose concentration in surrounding tissue. The signal is then detected and interpreted to give a reading indicative of blood glucose levels. Capsules containing glucose sensitive cells and electrodes for detecting electrical activity are also disclosed. Method of monitoring blood glucose are also described utilizing the systems and capsules disclosed.
Claims16
A capsule implantable in a patient's body, said capsule comprising a thin walled tube or a pellet and being constituted of:
- (a) glucose-sensitive living animal cells capable of producing an electrical signal in response to the glucose concentration in the medium surrounding the capsule in the patient;
- (b) a membrane enclosing the cells, the membrane being impermeable to the cells and any antibodies and large molecules to prevent immunological reactions, and being permeable to nutrients for and waste products form the cells to maintain viability of the cells;
- and
- (c) electrodes within the membrane for measuring the potential difference corresponding to the electrical activity of the cells;
- the dimensions of the capsule being sufficient to permit implantation in the patient's body and diffusion between the cells and the medium surrounding the capsule in the body.
A capsule implantable in a patient's body, said capsule comprising a thin walled tube or a pellet and being constituted of:
- (a) glucose-sensitive living animal cells capable of producing an electrical signal in response to the glucose concentration in the medium surrounding the capsule in the patient;
- (b) a membrane enclosing the cells, the membrane being impermeable to the cells and any antibodies and large molecules to prevent immunological reactions, and being permeable to nutrients for and waste products from the cells to maintain viability of the cells;
- and
- (c) means for shorting out the interior of the capsule with respect to the exterior of the capsule such that electrical activity of the cells is dissipated in the exterior;
- the dimensions of the capsule being sufficient to permit implantation in the patient's body and diffusion between the cells and the medium surrounding the capsule in the body.
A capsule implantable in a patient's body, said capsule comprising a thin walled tube or a pellet and being constituted of:
- (a) glucose-sensitive living animal cells capable of producing an electrical signal in response to the glucose concentration in the medium surrounding the capsule in the patient;
- and
- (b) a membrane enclosing the cells, said membrane containing or being coated with at least one dye whose optical properties are changed by the electrical signal produced by said cells, the membrane being impermeable to the cells and any antibodies and large molecules to prevent immunological reactions, and being permeable to nutrients for and waste products from the cells to maintain viability of the cells;
- the dimensions of the capsule being sufficient to permit implantation in the patient's body and diffusion between the cells and the medium surrounding the capsule in the body.
Dependencies are inferred from the claim text.