Recominbant Herpesvirus of Turkeys and live vector vaccines derived thereof
AssigneeAkzo N.V.
InventorsPulus J. A. Sondermeijer, Johannes A. Claessens, Albert P. A. Mockett
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Abstract
The present invention is concerned with a recombinant Herpesvirus of Turkeys (HVT), containing a heterologus gene incorporated into an insertion-region of the genome of HVT. The invention also relates to a vector vaccine comprising such a recombinant HVT which expresses a heterologous antigenic polypeptide and induces an adequate immune response on infection of an appropriate host animal.
Claims19
A recombinat comprising a heterologous nucleic acid sequence, said nucleic acid sequence being introduced in an insertion region of the HVT genome which comprises the genomic region from the end of ORF-1 through ORF-5 located within a DNA fragment of the HVT genome having a restriction enzyme map defined by FIG. 1.
A nucleic acid sequence comprising a gene heterologous to HVT, or part thereof, controlled by a promoter, flanked by DNA sequences derived from the insertion region of the HVT genome which corresponds to the HVT genomic region from the end of ORF-1 through ORF-5.
Dependencies are inferred from the claim text.