Tungsten-188/carrier-free rhenium-188 perrhenic acid generator system
AssigneeMartin Marietta Energy Systems, Inc.
InventorsFurn F. Knapp, Jr., Edward C. Lisic, Saed Mirzadeh, Alvin P. Callahan
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Abstract
A generator system for providing a carrier-free radioisotope in the form of an acid comprises a chromatography column in tandem fluid connection with an ion exchange column, the chromatography column containing a charge of a radioactive parent isotope. The chromatography column, charged with a parent isotope, is eluted with an alkali metal salt solution to generate the radioisotope in the form of an intermediate solution, which is passed through the ion-exchange column to convert the radioisotope to a carrier-free acid form.
Claims12
A method for generating carrier-free Re-188 perrhenic acid comprising the steps of:
- providing a chromatography column and a cation-exchange column;
- applying to said chromatography column a charge of W-188;
- eluting said chromatography column with a metal salt solution to generate Re-188 in the form of an intermediate solution;
- and,
- passing said intermediate solution through said cation-exchange column to convert said Re-188 to a carrier-free acid form.
A method for generating carrier-free Re-188 perrhenic acid comprising the steps of:
- providing a chromatography column and an anion-exchange column;
- applying to said chromatography column a charge of W-188;
- eluting said chromatography column with a metal salt solution to generate Re-188 in the form of an intermediate solution containing an ion of said metal;
- passing said intermediate solution through said anion-exchange column to retain said Re-188 thereon;
- eluting said anion-exchange column with a dilute acid to elute said metal ion;
- and,
- eluting said anion-exchange column with a strong acid to elute said carrier-free Re-188 perrhenic acid.
A method for generating a carrier-free Re-188 in the form of perrhenic acid comprising the steps of:
- providing a chromatography column and an cation-exchange column;
- applying to said chromatography column a charge of W-188;
- eluting said chromatography column with a dilute alkali metal salt solution to generate Re-188 in the form of an intermediate solution of a perrhenate salt;
- and,
- passing said intermediate solution through said cation-exchange column to convert said perrhenate salt to carrier-free Re-188 in the form of perrhenic acid.
A method for generating a carrier-free Re-188 in the form of perrhenic acid comprising the steps of:
- providing a chromatography column and an anion-exchange column;
- applying to said chromatography column a charge of W-188;
- eluting said chromatography column with a dilute alkali metal salt solution to generate Re-188 in the form of an intermediate solution of a perrhenate salt;
- passing said intermediate solution through said anion-exchange column to retain the Re-188 ion of said perrhenate salt thereon;
- eluting said anion-exchange column with a dilute acid to elute the alkali metal ion;
- and,
- eluting said anion-exchange column with a strong acid to elute carrier-free Re-188 in the form of perrhenic acid.
Dependencies are inferred from the claim text.