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US 5,185,444 AGranted
Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
AssigneeAnti-Gene Deveopment Group
InventorsJames E. Summerton, Dwight D. Weller
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Abstract
A polymer composition is disclosed composed of morpholino subunit structures linked together by uncharged, chiral linkages, one-three atoms in length. These chiral linkages join the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide.
Claims15
A polymer composition comprised of morpholino subunit structures of the form:
- ##STR2## where (i) the structures are linked together by uncharged phosphorous-containing, chiral linkages, one to three atoms long, joining the morpholino nitrogen of one subunit to the 5', exocyclic carbon of an adjacent subunit, and (ii) P.sub.i is a purine or pyrimidine base-pairing moiety effective to bind by base-specific hydrogen bonding to a base in a polynucleotide.
Dependencies are inferred from the claim text.