Method for production of T-butyl 3-oxobutyrates and their use
AssigneeTakeda Chemical Industries, Ltd.
InventorsKenzo Naito, Yukio Ishibashi, Haruo Shinbo
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Abstract
Disclosed are an advantageous method of industrial production of tert-butyl 3-oxobutylate, which is a useful intermediate for synthesis, characterized by reacting tert-butyl alcohol with diketene in the presence of 4-(tertiary amino) pyridine, and an industrially advantageous method of producing cephalosporin compounds or pharmaceutically acceptable salts thereof, using tert-butyl 3-oxobutylate as an intermediate.
Claims1
A method of producing tert-butyl 3-oxobutyrate, characterized by allowing tert-butyl alcohol to react with diketene at a temperature of 25.degree. C. to 80.degree. C. for 0.3 to 3 hours in the presence of a 4-(tertiary amino)pyridine of the formula:
- ##STR7## wherein Q.sup.1 and Q.sup.2 independently stand for a C.sub.1-6 group of are combined together with the adjacent nitrogen atom to form a cyclic amino group.
Dependencies are inferred from the claim text.