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US 5,183,829 AGranted
Oral liquid compositions of non-steroidal anti-inflammatory drugs
AssigneeApplied Analytical Industries, Inc.
InventorHenry C. Caldwell
Life of this patent
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Abstract
Pharmaceutically elegant oral compositions of non-steroidal anti-inflammatory drugs or their salts are prepared by adding selected dispersing agents such as a polyvinylpyrrolidone, hydroxypropyl-methylcellulose or hydroxypropylcellulose to the NSAIDs in a medium of polyol-glycol-alcohol. The compositions offer the formation of finely dispersed active ingredients upon dispersion in gastric juice.
Claims12
A one phase liquid composition for oral administration comprising:
- (a) An anti-inflammatory but non-toxic quantity of a non-steroidal, anti-inflammatory drug in carboxylic acid form or a non-toxic, pharmaceutically acceptable alkali metal or ammonium salt thereof;
- (b) a pharmaceutically acceptable quantity of a glycol which is propylene glycol or a polyethylene glycol selected from the range of 15-50% v/v;
- (c) a quantity of ethanol selected from the range of 0-20% v/v;
- (d) a pharmaceutically acceptable quantity of a polyol which is glycerin or sorbitol selected from the range of 30-80% v/v;
- and
- (e) a pharmaceutically acceptable quantity of a dispersing agent which is polyvinylpyrrolidone, hydroxypropylcellulose or hydroxypropylmethylcellulose and which is selected form the range of 50:1 to 1:3 w/w of drug:
- dispersing agent.
4 more elements
Dependencies are inferred from the claim text.