Polyhydroxybenzoic acid derivatives
OwnerBartholomeus van't Riet, Howard L. Elford +1inventors
InventorsBartholomeus van't Riet, Howard L. Elford, Galen L. Wampler
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Abstract
Polyhydroxy-substituted benz, phenylacet and mandelamidines, amidates, amidoximes and hydroxyamidoximes--ribonucleotide reductase inhibitors, and free radical scavengers.
Claims2
A pharmaceutical formulation in unit dosage form for parenteral administration containing a compound of the following formula plus one or more pharmaceutically-acceptable excipients ##STR19## in which n is 2-5m, m is 0 or 1, R" is H or OH, R' is NH or NOH and R is NH.sub.2, NHOH or O-C.sub.1-3 alkyl, subject to the provisos that when R' is NH, R can only be NH.sub.2 or NHOH and that when R' is NOH, R can only be NH.sub.2 or O-C.sub.1-3 alkyl.
The method of scavenging free-radicals generated in-vivo in a mammal having a disease condition involving excess free-radical formation which comprises administering to said diseased mammal in a pharmaceutically-acceptable formulation an amount of a compound of the following formula in an amount effective to decrease free-radical concentration ##STR20## in which n is 2-5, m is 0 or 1, R" is H or OH, R' is NH or NOH, R is NH.sub.2, O-C.sub.1-3 alkyl or NHOH;
- subject to the provisos that when R' is NOH, R can only be NH.sub.2 or NOH and that when R' is NH, R can only be NH.sub.2 or O-C.sub.1-3 alkyl, or a salt thereof.
Dependencies are inferred from the claim text.