Back to results
US 5,183,819 AGranted
Use of fused bicyclic imides in the treatment of various CNS disorders
AssigneeAmerican Home Products Corporation
InventorsMagid A. M. Abou-Gharbia, John A. Moyer
Life of this patent
Estimating the term…
Abstract
The invention relates to a method of treating alcoholism, sleep disorders or behavioral symptoms of Alzheimer's disease which comprises administration of bridged 2-(4-arylpiperazin-1-ylalkyl)-hexahydroisoindol-1,3-dione derivatives to a warm-blooded animal in need thereof.
Claims2
A method of treating alcoholism, behavioral symptoms of Alzheimer's disease or sleep disorders which comprises administration to a mammal in need thereof a therapeutically effective amount of a compound having the formula:
- ##STR7## wherein:
- n is 0-4;
- m is 2-4;
- R.sup.1 and R.sup.2 are H or R.sup.1 and R.sup.2 taken together forms a 3-5 membered carbocyclic ring;
- R.sup.3 and R.sup.4 are H or R.sup.3 and R.sup.4 taken together form a 3-6 membered carbocylic ring;
- with a proviso that when R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are other than hydrogen, n is other than zero;
- X is lower alkylene, vinylene or oxygen;
- R.sup.5 is unsubstituted or substituted phenyl, 2-pyridinyl, 2-pyrimidinyl, 2-pyrazinyl or 3-pyrazinyl where the substituents are selected from lower alkyl, lower alkoxy, halo, cyano, nitro and trifluoromethyl;
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.