Glycerol derivative and anti-hypertensive agent
AssigneeNippon Chemiphar Co., Ltd.
InventorsMitsuo Masaki, Hiromitsu Takeda, Toshiro Kamishiro, Masao Yamamoto
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Abstract
A novel glycerol derivative which is effective to reduce blood pressure has the formula: ##STR1## wherein R.sup.1 is an alkyl group having 10-22 carbon atoms, R.sup.2 is lower acyl, benzoyl, aryl, mono-, di- or triarylalkyl, alkyl, cycloalkyl, or cycloalkylalkyl; Q is substituted or unsubstituted alkylene containing 1-4 carbon atoms, l is 0 or 1; Y is a nitrogen-containing heterocyclic group or a nitrogen-containing bridged heterocyclic group (--(Q).sub.l -- is attached to a carbon atom contained in a hetero-ring of the heterocyclic group) in which Y is the bridged heterocyclic group where l is 0; and each of R.sup.5, R.sup.6 and R.sup.7 is hydrogen, lower alkyl, aryl or aralkyl.
Claims6
A glycerol derivative having the formula:
- ##STR14## wherein R.sup.1 is a straight or branched chain alkyl group having 10-22 carbon atoms:
- R.sup.2 is a straight or branched chain acyl group having 1-6 carbon atoms or benzoyl;
- R.sup.5, R.sup.6 and R.sup.7 are independently hydrogen or a straight or branched chain alkyl group having 1-6 carbon atoms;
- Q.sub.l is a saturated or unsaturated alkylene divalent bridging radical having 1-4 carbon atoms optionally substituted by one or two methyl or phenyl groups.
- l is 1;
- and
- Y represents a heterocyclic group selected from the group consisting of 2-or-3-pyrrolidinyl, 2-3-or-4-piperdinyl, 2-morpholinyl, 2-or-3-perhydroazepinyl, 5-oxazolyl, 2-(1,2,3,4-tetrahydroquinolinyl), 2-or-3-(1,2,3,4-tetrahydroisoquinolinyl, 3-isoquinolinyl, 3-(1,2,5,6,-tetrahydropyridyl), and 3-pyridyl, which has a moiety represented by ##STR15## wherein R.sup.3 and R.sup.4 are independently a straight or branched chain alkyl group having 1-6 atoms, and said heterocyclic group optionally has one or two substituents selected from the group consisting of a straight or branched chain alkyl group having 1-6 carbon atoms or phenyl, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.