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US 5,183,808 AGranted
Method for treating fungal infections with serine analogs of BU-3608 antibiotics
AssigneeBristol-Myers Squibb Company
InventorsYosuke Sawada, Masatoshi Kakushima, Maki Nishio, Takeo Miyaki, Toshikazu Oki
Life of this patent
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Abstract
Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.
Claims1
A method for treating fungal infections in a mamalian host which comprises administering to said host an antifungally effective amount of a compound having the formula ##STR7## wherein the serine is D-serine;
- R.sup.1 and R.sup.2 are independently H or C.sub.1-16 alkyl;
- and R.sup.3 is H or .beta.-D-xylosyl;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.