Use of monosialoganglioside GM, to prevent the development of tolerance to the analgesic effect of morphine and related drugs
AssigneeFidia S.p.A.
InventorsFrancesco della Valle, Gino Toffano
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Abstract
The use of monosialoganglioside GM.sub.1, of its pharmacologically acceptable salts and of its internal ester derivative for the preparation of pharmaceutical compositions for preventing the development in man of tolerance to the analgesic effect of morphine, of chemically correlated opiates, and of methadone and its derivatives is described.
Claims8
A method for preventing the development of tolerance to the analgesic effect of morphine, of chemically correlated opiates and of methadone and its derivatives, which comprises administering to patients in need thereof, either prior to, contemporaneously with or successively to the analgesic administration of said compounds, a therapeutically effective amount of the ganglioside GM.sub.1, its pharmacologically acceptable salts or its internal ester derivative, alone or together in mutual association.
Dependencies are inferred from the claim text.