US 5,183,766 A · Dispersion polymers, processes for their preparation and their use

Abstract

Dispersion polymers, processes for their preparation and their use are disclosed. The dispersion polymers being obtained by a seed polymerization process in the presence of seed latices with a high residual monomer content and a monomer mixture of at least one compound of the formula I ##STR1## wherein n=1-6; R.sub.1 =H or CH.sub.3 and R.sub.2 and R.sub.3 are identical or different, where R.sub.2 and R.sub.3 =--(CH.sub.2).sub.m --CH.sub.3, and m=0-7, or ##STR2## in which X, Y and Z=(CH.sub.2).sub.p --CH.sub.3 and p=1-3, where X, Y and Z are identical or different, or R.sub.2 and R.sub.3 =an aryl radical, and if appropriate acrylic acid, methacrylic acid, crotonic acid and monomers from which the seed latex is prepared. The invention furthermore relates to the biologically active latex conjugates which are obtained using the dispersion polymers and are particularly suitable for serological and immunological determination methods.

Claims16

Dependent claims

A process for the preparation of a dispersion polymer, which comprises the steps of first preparing a latex of a non-film-forming seed polymer having an incompletely polymerized monomer content of 5 to 50% by weight by carrying out the polymerization so that only 30% to 90% of the monomer present is polymerized completely, subsequently separating off the monomers not bonded to the polymer and then polymerizing a monomer mixture which contains at least one compound of the formula I containing acetal groups ##STR5## wherein n is 1-6;

R.sub.1 is H or CH.sub.3 ;
and
R.sub.2 and R.sub.3 are identical or different, where
R.sub.2 and R.sub.3 are (CH.sub.2).sub.m --CH.sub.3, and m is 0-7, or ##STR6## in which X, Y and Z are (CH.sub.2).sub.p --CH.sub.3 and P is 1--3, where X, Y and Z are identical or different, or R.sub.2 and R.sub.3 are an aryl radical,
and, in addition, up to 30% by weight, based on the mixture, of monomrs selected from acrylic acid, methacrylic acid, crotonic acid and mixtures thereof, and a further up to 30% by weight, again based on the total mixture, of carbocyclic aromatic vinylidene monomers in the presence of the seed polymer thus obtained.

2 more elements

A process for the preparation of a biologically active dispersion polymer comprising the steps of:

(1) preparing a latex of non-film-forming seed polymer having an incompletely polymerized monomer content of from about 5 to 50% by weight;
(2) polymerizing in the presence of the seed polymer a monomer mixture which contains at least one compound of the formula I containing acetal groups ##STR9## wherein n is 1-6;
R.sub.1 is H or CH.sub.3 ;
and
R.sub.2 and R.sub.3 are identical or different, where R.sub.2 and R.sub.3 are (CH.sub.2).sub.m --CH.sub.3, and m is 0-7, or ##STR10## in which X, Y and Z are (CH.sub.2).sub.p --CH.sub.3 and P is 1-3, where X, Y and Z are identical or different, or R.sub.2 and R.sub.3 are an aryl radical,
and, in addition, up to 30% by weight, based on the mixture, of monomers selected from acrylic acid, methacrylic acid, crotonic acid and mixtures thereof, and a further up to 30% by weight, again based on the total mixture, of carbocyclic aromatic vinylidene monomers;
(3) adjusting the pH of the resulting polymer latex to a pH of less than about 5;
and
(4) incubating the resultant polymer latex with the biologically active material to be bound thereto in the presence of a reducing agent.

6 more elements

Dependencies are inferred from the claim text.

Dispersion polymers, processes for their preparation and their use

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Dispersion polymers, processes for their preparation and their use

Life of this patent

Abstract

Claims16