Quantitative analysis for diabetic condition predictor involving chiro-inositol
AssigneeThe University of Virginia Alumni Patents Foundation
InventorsAlison S. Kennington, Joseph Larner
Life of this patent
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Abstract
An enhanced quantitative assay for chiro-inositol concentration can be used to determine insulin-resistance, or a predeposition to the development of insulin-resistance, in type I and type II diabetics. Spot urine or serum samples reflecting concentrations of chiro-inositol below about 1.0 micrograms/ml in urine or 0.1 micrograms/ml in serum are indicative of a predisposition to the development of insulin-resistance, while concentrations below about 0.3 micrograms/ml or 0.03 micrograms/ml in serum are associated with actual insulin-resistance symptoms. The assay can be employed for patient diagnosis, insulin therapy monitoring, and family screening.
Claims3
A method for screening mammalian individuals to determine whether the individual exhibits insulin-resistance associated with a diabetic state, comprising:
- obtaining a sample from said individual, said sample being selected from the group consisting of a serum sample, and a urine sample,
- determing the concentration of chiro-inositol (CI) in said sample,
- correlating said concentration with preestablished values indicating insulin-resistance in mammalian individuals,
- wherein said preestablished values are less than about 0.3 micrograms/ml for urinary CI concentrations and less than about 0.03 micrograms/ml for serum CI concentrations being indicative of insulin-resistance.
A method for screening mammalian individuals to determine whether said individuals exhibit presymptomatic insulin-resistance, comprising:
- obtaining a sample from said individual, said sample being selected from the group consisting of a serum sample and a urine sample,
- determing the concentration of chiro-inositol (CI) in said individual,
- correlated said CI concentration with preestablished values indicting presymptomatic insulin-resistance in mammalian individuals,
- wherein said preestablished values are between about 0.3-1.0 micrograms/ml for urinary CI concentrations and between about 0.03-0.1 micrograms/ml for CI serum concentrations being indicative of presymptomatic insulin-resistance in mammalian individuals.
A method for screening mammalian individuals to determine whether said individuals exhibit insulin-resistance, comprising:
- obtaining a sample from said individual, said sample being selected from the group consisting of a serum sample and a urine sample,
- determing the concentration of chiro-inositol in said individual,
- correlating said chiro-inositol concentration with preestablished values indicating insulin-resistance in mammalian individuals,
- wherein said preestablished values are between about 0.3-1.0 micrograms/ml for urinary chiro-inositol concentrations and between about 0.03-0.1 micrograms/ml for chiro-inositol serum concentrations being indicative of insulin-resistance in mammalian individuals.
Dependencies are inferred from the claim text.