US 5,183,690 AGranted

Starch encapsulation of biologically active agents by a continuous process

AssigneeThe United States of America as represented by the Secretary of Agriculture

InventorsMerle E. Carr, William M. Doane, Robert E. Wing, Edward B. Bagley

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Abstract

Biologically active agents to be encapsulated are continuously blended with a starchy material and water, subjected to high-shear mechanical action at a temperature above the gelatinization temperature of starch, and continuously recovered as an insolubilized matrix of starch that entraps discontinuous domains of the agent. Alternatively, the core material to be encapsulated is added and blended with the aqueous dispersion of starch after the starch and water have been subjected to an elevated temperature sufficient to gelatinize the starch. Rate of release of agents to the environment can be controlled by preselecting a set of conditions related to various processing parameters. Encapsulation of biologically active compositons provides protection against degradative environmental conditions, improves safety in handling, and slows the release of such compounds to the surrounding medium.

Claims7

Dependent claims

A continuous process for imparting predetermined release properties to an encapsulated biologically active agent in a matrix of starchy material comprising the steps:

a. establishing an array of processing parameters in a process for producing said encapsulated biologically active agent by extrusion, which parameters have an effect on the release properties of the active agent from the matrix of starchy material;
b. preselecting a set of conditions defined by the parameters, which set of conditions will yield the predetermined release properties;
c. continuously blending the starchy material, the active agent, and water in an ingredient stream, wherein the starchy material is at a solids concentration of at least 40% and comprises an unmodified regular or waxy cereal, potato, or tapioca starch or a flour containing said starch, or a mixture of these starches or flours;
d. continuously extruding said ingredient stream as an extrudate;
and
e. continuously recovering the extrudate;
wherein the conditions of blending, extruding, and recovering comprise said set of conditions whereby the extrudate is an encapsulated biologically active agent having the predetermined release properties.

4 more elements

Dependencies are inferred from the claim text.