Composition for percutaneous administration and method for enhancing percutaneous absorption of a physiologically active ingredient empolying the same

A method for enhancing percutaneous permeability and absorption of a physiologically active ingredient comprising percutaneously administering:

• (a) a pharmaceutically effective amount of a physiologically active ingredient selected from at least one member of the group consisting of a benzodiazepin, a diuretic, a hypertensive, an ethylenediamine, a non-steroid anti-inflammatory agent, sodium salicylate, an anti-cancer agent, a steroid anti-inflammatory agent, an anti-epileptic, an anti-arrhythmic, a psychoneurotropic agent, an antibiotic and a central nervous system stimulant, wherein said pharmaceutically effective amount is about 0.01 to 20% by weight of the total composition, and
• (b) a percutaneous absorption enhancing effective amount of an anti-histamine selected from the group consisting of diphehydramine, clematine, cyproheptadine, triperenamine, diphenylpyraline, chlorpheniramine, promethazine, doxylamine, dimenhydrimate, tripelennamine, methapyrilene, pyrilene, thonzylamine, prophenpyridamine and chlorcyclizine, wherein said percutaneous absorption enhancing effective amount is about 0.01 to 20% by weight of the total composition,
• wherein component (A) is a different compound from component (B).