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US 5,183,662 AGranted
Controlled drug release composition
AssigneeSenju Pharmaceutical Co., Ltd.
InventorsYasushi Morita, Akira Ohtori, Masako Andoh
Life of this patent
Estimating the term…
Abstract
The present invention is concerned with a controlled drug release composition comprising a poorly soluble drug, a water-soluble macromolecular compound and biodegradable macromolecular compound, which composition can be freely tailored to the required solubility and release pattern of the poorly soluble drug through adjustment of the ratio of said ingredients.
Claims3
A controlled drug release composition which comprises at least one poorly soluble steroidal drug;
- at least one water-soluble macromolecular compound selected from the group consisting of polyvinylpyrrolidone, polyethylene glycol and hydroxypropylcellulose in a proportion of 3 to 5 weight parts per weight part of the poorly soluble drug;
- and at least one biodegradable macromolecular compound selected from the group consisting of polylactic acid, polyglycolic acid and the corresponding copolymers thereof in a proportion of 1 to 3 parts per weight part of the poorly soluble drug.
A controlled drug release composition in dosage form of a rod or sheet which comprises at least one poorly soluble steroidal drug;
- at least one water-soluble macromolecular compound selected from the group consisting of polyvinylpyrrolidone, polyethylene glycol and hydroxypropylcellulose in a proportion of 3 to 5 weight parts per weight part of the poorly soluble drug;
- and at least one biodegradable macromolecular compound selected from the group consisting of polylactic acid, polyglycolic acid and the corresponding copolymers thereof in a proportion of 1 to 3 parts per weight part of the poorly soluble drug.
Dependencies are inferred from the claim text.