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US 5,182,387 AGranted
Bis-dibenzoazepine compounds
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsJules Freedman, Alan J. Bitonti
Life of this patent
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Abstract
Novel bis-dibenzoazepine compounds useful in the treatment of malaria and drug-resistant malaria.
Claims15
A compound of the formula:
- ##STR15## or a pharmaceutically acceptable salt thereof, wherein
- X is O or H.sub.2 ;
- R.sub.1 and R.sub.2 are each independently H, C.sub.1 -C.sub.4 alkyl, benzyl, or phenethyl, or, when there is a bond between R.sub.1 and R.sub.2 as represented by the dotted line, R.sub.1 and R.sub.2 taken together are ethylene;
- Y and Z are each independently H, Cl, F, Br, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy or CF.sub.3 moiety;
- n is an integer of 1 to 10;
- and
- p and q are each independently an integer of 2 to 4,
- provided that when there is a bond between R.sub.1 and R.sub.2, X is H.sub.2 and n is 1.
5 more elements
Dependencies are inferred from the claim text.