Stable, crystalline form of a cephalosporin intermediate product
AssigneeBiochemie Gesellschaft m.b.H.
InventorsBernhard C. Prager, Karl Wessely, Werner Veit
Life of this patent
Estimating the term…
Abstract
The invention relates to new stable, crystalline forms of the t-butylester of ceftazidime of formula ##STR1## and the production thereof.
Claims3
The crystalline, stable form of (6R,7R)-7-[[2-(2-amino-4-thiazolyl)-(Z)-2-(1-tert.butoxycarbonyl-1-methyle thoxy)imino]acetamido]-3-(1-pyridiniummethyl)-3-cephem-4-carboxylate (ceftazidime-t-butylester) of formula ##STR6## having the X-ray spectrum
- ______________________________________ d (.ANG.) I ______________________________________ 17.0 w 15.5 m 5.9 w 5.0 w 4.15 w 3.84 w 3.3 w ______________________________________ w = weak m = medium
- (.alpha.-form).
The crystalline, stable form of (6R,7R)-7-[[2-(2-amino-4-thiazolyl)-(Z)-2-(1-tert.butoxycarbonyl-1-methyle thoxy)imino]acetamido]-3-(1-pyridiniummethyl)-3-cephem-4-carboxylate (ceftazidime-t-butylester) of formula I, having the X-ray spectrum
- ______________________________________ d (.ANG.) I ______________________________________ 22.0 m 10.0 w 8.5 m 7.3 w 6.7 m 5.9 md 5.6 m 5.3 wd 4.2 w 3.94 w 3.82 w 3.7 w 3.3 w ______________________________________ w:
- weak m:
- medium d:
- diffuse
- (.beta.-form).
Dependencies are inferred from the claim text.