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US 5,182,374 AGranted
Clindamycin phosphate synthesis
AssigneeAmerican Cyanamid Company
InventorsMartin Tobkes, Simon Diaz, Lalitha Krishnan
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Abstract
An improved process for producing the antibiotic compound clindamycin phosphate through the use of novel intermediate, 7(S)-chloro-7-deoxylincomycin-2-bis(2,2,2-trichloroethyl)phosphochloridate and similar compounds.
Claims4
A compound of the formula:
- ##STR6## where R.sub.1 is lower alkyl, R.sub.2 is lower alkyl or hydrogen, X is Cl or Br and Y is ##STR7##
A compound of the formula:
- ##STR8## wherein X is Cl or Br, R.sub.1 is lower alkyl, and R.sub.2 is lower alkyl or hydrogen.
A compound of the formula:
- ##STR9## wherein X is Cl or Br, R.sub.1 is lower alkyl and R.sub.2 is lower alkyl or hydrogen.
A compound of the formula:
- ##STR10## where R.sub.1 is lower alkyl, R.sub.2 is lower alkyl or hydrogen and X is Cl or Br.
Dependencies are inferred from the claim text.