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US 5,182,368 AGranted
Ligands and methods for augmenting B-cell proliferation
OwnerJeffrey A. Ledbetter, Edward A. Clarkinventors
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Abstract
A new B-cell receptor, Bp50, a 50 kilodalton polypeptide, that functions in B-cell proliferation is described. Ligands such as lymphokines, antibody molecules or the Fv fragments of antibody molecules that bind to Bp50 and augment the proliferation of activated B-cells can be used to regulate B-cell proliferation or differentiation.
Claims11
A substantially pure ligand that (a) binds to Bp50, a 50 kilodalton B-cell surface antigen defined by monoclonal antibody G28-5;
- (b) upon binding to an activated B-cell stimulates the activated B-cell to traverse the cell cycle so that proliferation of the B-cell is augmented;
- and (c) upon binding to resting B-cells does not, in the absence of other factors, stimulate proliferation which ligand is the monoclonal antibody produced by a hybridoma cell line as deposited with the ATCC and having accession number HB9110, or an Fv, Fab, F(ab').sub.2 or Fab' portion of said monoclonal antibody.
Dependencies are inferred from the claim text.