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US 5,182,367 AGranted
5-lipoxygenase activating protein
AssigneesMerck & Co., Inc., Merck Frosst Canada, Inc.
InventorsJohn W. Gillard, Jacques-Yves Gauthier, Jillian F. Evans, Rejean Fortin, Yvan Guinon, Richard A. F. Dixon, Douglas K. Miller
Life of this patent
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Abstract
An 18kD protein (FLAP) has been isolated from rat and human cells which is necessary for production of leukotrienes from arachidonic acid in mammalian cells containing 5-lipoxygenase. The gene (cDNA) encoding for FLAP has also been produced.
Claims3
The essentially pure 5-lipoxygenase activating protein (FLAP), characterized in that it has a molecular weight of 18 kD as determined by SDS-PAGE under reducing conditions.
Dependencies are inferred from the claim text.