Osteogenic proteins
AssigneeStryker Corporation
InventorsHermann Oppermann, Thangavel Kuberasampath, David C. Rueger, Engin Ozkaynak
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Abstract
Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid composition, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.
Claims16
A protein, produced by expression of recombinant DNA in a host cell substantially of other contaminating proteins and comprising a pair of polypeptide chains, each of which has less than about 200 amino acids in a sequence sufficiently duplicative of the sequence of COP-5 or COP-7 such that said pair of polypeptide chains, when disulfide bonded to produce a dimeric species, has a conformation capable of inducing bone or cartilage formation in association with a matrix when implanted in a mammal.
A protein, substantially free of other contaminating proteins comprising the amino acid sequence:
- ##STR30##
A protein, substantially free of other contaminating proteins comprising the amino acid sequence:
- ##STR31##
Dependencies are inferred from the claim text.