Polypeptide analogs of apolipoprotein E
AssigneeThe Scripps Research Institute
InventorsCheryl A. Dyer, Linda K. Curtiss, Richard Smith
Life of this patent
Estimating the term…
Abstract
The present invention contemplates a method for treating hypercholesterolemia in a patient, which method comprises administering to the patient an LDL plasma concentration-reducing amount of a multimeric polypeptide capable of binding the LDL receptor. THe repeating unit of the polypeptide has an amino acid residue sequence corresponding to that represented by the formula LRKLRKRLLRDADDL.
Claims1
A composition for modulating hepatic uptake of low density lipoprotein comprising a therapeutically effective amount of a polypeptide having an LDL-receptor binding segment and an LDL binding segment, said LDL-receptor binding segment having an amino acid residue sequence represented by the formula:
- Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-Arg-Asp-Ala-Asp-Asp-Leu-Leu-Arg-Lys-Leu -Art-Lys-Arg-Leu-Leu-Arg-Asp-Ala-Asp-Asp-Leu,
- and said LDL binding segment having an amino acid residue sequence represented by the formula:
- Glu-Trp-Leu-Lys-Ala-Phe-Tyr-Glu-Lys-Val-Leu-Glu-Lys-Leu-Lys-Glu-Leu-Phe, and a suitable carrier therefor.
Dependencies are inferred from the claim text.