Treatment of osmotic disturbance with organic osmolytes
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsSteven R. Gullans, Charles W. Heilig
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Abstract
A method of treating an osmotic disturbance in an animal which comprises administering to an animal an effective amount of an organic osmolyte, wherein the organic osmolyte is a polyol. Specific polyols include myo-inositol and sorbitol. Also included are precursors of organic osmolytes including precursors of polyols. Other polyol precursors are selected from the group consisting of glucose, glucose polymers, and glycerol. Also inclu This invention was funded by a research grant from the National Institutes of Health, 1RO1 DK36031, which provides to the United States Government certain rights in the invention.
Claims14
A method of treating osmotic disturbance in an animal, which comprises administering enterally or parentally to said animal an effective amount of an organic osmolyte, wherein the organic osmolyte is a polyol.
A method of treating osmotic disturbance in an animal, which comprises administering enterally or parentally to said animal an effective amount of a precursor of a organic osmolyte, wherein the organic osmolyte is a polyol.
A method of preventing an osmotic disturbance substantially associated with physical activity comprising enterally administering to a subject prior to, during, or both prior to and during said physical activity an effective amount of an organic osmolyte or a precursor of an organic osmolyte, whereinsaid organic osmolyte or precursor is a polyol.
Dependencies are inferred from the claim text.