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US 5,182,298 AGranted
Cholesterol lowering agents
AssigneeMerck & Co., Inc.
InventorsGregory L. Helms, Wendy S. Horn, E. Tracy T. Jones, David L. Linemeyer
Life of this patent
Estimating the term…
Abstract
This invention relates to compounds of structural formula (I) ##STR1## which are useful as Cholestrol lowering agents.
Claims13
A compound of structure (I):
- ##STR6## wherein Z is selected from the group consisting of:
- a) H;
- b) C.sub.1-5 alkyl;
- c) C.sub.1-5 alkyl substituted with a member of the group consisting of
- i) phenyl,
- ii) phenyl substituted with methyl, methoxy, halogen (Cl, Br, I, F) or hydroxy;
- or
- a pharmaceutically acceptable salt of a compound of formula (I).
5 more elements
A compound of molecular formula C.sub.31 H.sub.40 O.sub.8 and molecular weight 540 characterized by
- (a) the .sup.13 C NMR chemical shifts (125 MHz) as measured in CDCl.sub.2 at 20.degree. C.;
- 12.3, 13.3, 14.8, 17.8, 21.0, 23.3, 27.3, 35.6, 40.2, 44.1, 47.3, 53.3, 70.2, 78.2, 79.7, 91.9, 119.7, 128.2, 128.3, 128.9, 129.1, 130.4, 130.6, 136.1, 137.0, 140.5, 142.8, 145.7, 171.5, 175.6, 209.1 ppm;
- (b) the .sup.13 C NMR chemical shifts (125 MHz) as measured in CD.sub.3 CN/CD.sub.2 Cl.sub.2 at 20.degree. C.;
- 11.9, 13.2, 14.8, 18.1, 21.1, 23.3, 27.6, 35.8, 40.4, 44.9, 47.8, 54.2, 70.2, 78.0, 80.2, 92.0, 120.9, 128.5, 128.6, 129.2, 129.3, 131.1, 131.5, 136.2, 137.2, 141.3, 141.6, 145.2, 168.0, 175.4, 209.9 ppm;
- (c) an .sup.1 H NMR spectrum (500 MHz) in CD.sub.2 Cl.sub.2, as shown in FIG. 1;
- (d) UV spectrum in methanol wherein .lambda..sub.max is at 240 and 340 nm;
- (e) IR spectrum wherein representative peaks are 1726, 1709, 1610, 1570, 1455 and 1410 cm.sup.-1.
4 more elements
Dependencies are inferred from the claim text.