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US 5,182,293 AGranted
Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsSai P. Sunkara, Winton D. Jones
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Abstract
This invention relates to pyridinyloxazole-2-ones which are useful in the treatment of multi-drug resistant tumors. The pyridinyloxazole-2-ones act to prevent drug resistance and thus allow conventional chemotherapeutic agents to kill tumor cells as if drug resistance were not present.
Claims1
A method of reversing vinblastine resistance in a patient having a vinblastine resistant tumor which comprises administering to said patient as effective amount of a compound of the formula:
- ##STR5## wherein R is C.sub.1-6 alkyl;
- and
- R.sub.1 is 2-, 3- or 4-pyridyl group;
- or a pharmaceutically acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.