Pyrozala-pyridyl aminoabkoxyphenol compounds

An aminoalkoxyphenyl compound of formula:

• ##STR174## in which:
• R is selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-6 cycloalkyl, benzyl and phenyl optionally substituted with one or more substituents, which may be identical or different, selected from halogen, lower C.sub.1-4 -alkyl, lower C.sub.1-4 alkoxy and nitro;
• R.sub.1 and R.sub.2, which are identical or different, are selected from hydrogen, methyl, ethyl and halogen;
• A is selected from a straight- or branched-alkylene radical having from 2 to 5 carbon atoms, a 2-hydroxypropylene radical, and a 2-(lower alkoxy)propylene radical;
• Alk is selected from a single bond and a linear- or a branched-alkylene radical having from 1 to 5 carbon atoms;
• R.sub.5 is selected from pyridyl, phenyl, 2,3-methylenedioxyphenyl, 3,4-methylenedioxyphenyl and phenyl substituted with one or more substituents which may be identical or different, selected from halogen, C.sub.1-8 alkyl and C.sub.1-8 alkoxy;
• R.sub.4 is selected from hydrogen and C.sub.1-8 alkyl, as well as the N-oxide derivative thereof and the pharmaceutically acceptable salt thereof.

An aminoalkoxyphenyl compound of formula:

• ##STR175## in which:
• R.sub.1 and R.sub.2, which are identical or different, are selected from hydrogen, methyl, ethyl and halogen;
• A is selected from a straight- or branched-alkylene radical having from 2 to 5 carbon atoms, a 2-hydroxypropylene radical, and a 2-(lower alkoxy)propylene radical;
• R.sub.3 represents a C.sub.1-8 alkyl radical;
• R.sub.4 is selected from hydrogen and C.sub.1-8 alkyl;
• R is selected from hydrogen, C.sub.1-8 alkyl, C.sub.3-6 cycloalkyl, benzyl and phenyl optionally substituted with one or more substituents, which may be identical or different, selected from halogen, lower C.sub.1-4 alkyl, lower C.sub.1-4 alkoxy and nitro;
• as well as the N-oxide derivative thereof and a pharmaceutically acceptable salt thereof.

An aminoalkoxyphenyl derivative of formula:

• ##STR176## in which:
• B is selected from --S--, --SO-- and --SO.sub.1 --;
• R is selected from hydrogen, linear- or branched-alkyl, cycloalkyl containing at most 6 carbon atoms and phenyl which is unsubstituted or substituted with one or more substituents, which may be identical or different, selected from halogen, lower C.sub.1-4 alkyl, lower C.sub.1-4 alkoxy and nitro;
• R.sub.1 and R.sub.2, which are identical or different, are selected from hydrogen, methyl, ethyl and halogen;
• A is selected from linear- or branched-alkylene having from 2 to 5 carbon atoms and 2-hydroxypropylene;
• R.sub.3 is selected from linear- or branched-C.sub.1-8 alkyl and a radical of formula Alk-R.sub.5, in which Alk denotes a single bond or a linear- or branched-alkylene radical having from 1 to 5 carbon atoms, and R.sub.5 is selected from pyridyl, phenyl, 2,3-methylenedioxyphenyl, 3,4-methylenedioxyphenyl and phenyl substituted with one or more substituents which may be identical or different, selected from halogen, lower C.sub.1-4 -alkyl and lower C.sub.1-4 alkoxy;
• R.sub.4 is selected from hydrogen and alkyl;
• as well as a pharmaceutically acceptable salt of this derivative.

An aminoalkoxyphenyl compound of formula:

• ##STR177## in which:
• B is selected from --S--, --SO-- and --SO.sub.1 --;
• R is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tertbutyl, 1-methyl-propyl, n-pentyl, neopentyl, phenyl, monofluoro-, monochloro- or monobromophenyl, difluoro-, dichloro-, or dibromophenyl, monomethyl- or dimethylphenyl, monomethoxy or dimethoxyphenyl, nitrophenyl and methylphenyl substituted with a halogen atom;
• R.sub.1 and R.sub.2, which are identical or different, are selected from hydrogen, chlorine, bromine, iodine and methyl;
• A is selected from 1,2-ethylene, 1,3-propylene, 2-methyl-1,3-propylene, 1,4-tetramethylene, 1,5-pentamethylene and 2-hydroxypropylene;
• R.sub.3 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, 1-methylpropyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, phenyl, benzyl, phenethyl, methoxyphenethyl, dimethoxyphenethyl, dimethylphenethyl, dimethoxyphenyl, dimethoxybenzyl and pyridyl ethyl or phenethyl substituted in the aromatic portion with methyl and methoxy radicals;
• R.sub.4 is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tertbutyl, n-pentyl, neopentyl, n-hexyl, n-heptyl and n-octyl;
• as well as a pharmaceutically acceptable salt of this derivative.