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US 5,182,287 AGranted
Bioactive heterocycle alkaloids and methods of use
AssigneeHarbor Branch Oceanographic
InventorsGeewananda P. Gunawardana, Peter J. McCarthy, Neal S. Burres
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Abstract
Novel heterocyclic alkaloids were isolated from a marine sponge. These compounds, and derivatives thereof, are useful antifungal and antitumor compounds. The novel compounds have the following structures: ##STR1## wherein R.sub.1 =H, alkyl, alkenyl, aryl, benzyl, acyl, benzoyl, or alkali metal; R.sub.2 and R'.sub.2 =O, S, NOX, or NNHX, wherein X is alkyl or aryl.
Claims14
A compound having the following structure:
- ##STR4## wherein R.sub.1 =H, alkyl, alkenyl, aryl, benzyl, acyl, benzoyl, or alkali metal;
- R.sub.2 =O, S, NOX, or NNHX, wherein X is alkyl or aryl.
A compound having the following structure:
- ##STR5## wherein R.sub.2 and R'.sub.2 =O, S, NOX, or NNHX, wherein X is alkyl or aryl.
Dependencies are inferred from the claim text.