Heterocyclic compounds their preparation and use
AssigneeNovo Nordisk A/S
InventorJohn S. Ward
Life of this patent
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Abstract
The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease.
Claims35
A compound which is 3-(3-Methoxypyrazinyl)-1,2,5,6-tetrahydro-1-methyl-pyridine or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Butyloxypyrazinyl)-1,2,5,6-tetrahydro-1-methyl-pyridine or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Hexyloxypyrazinyl)-1,2,5,6-tetrahydro-1-methyl-pyridine or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-(2-Methoxyethoxy)pyrazinyl)-1,2,5,6-tetrahydro-1-methylpyridine or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Chloropyrazinyl)-1,2,5,6-tetrahydro-1-methylpyridine or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Chloropyrazinyl)-1-azabicyclo[2.2.2]oct-2-ene or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Methoxypyrazinyl)-1-azabicyclo[2.2.2]oct-2-ene or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Methoxypyrazinyl)-1-azabicyclo[2.2.2]octane or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Hexyloxypyrazinyl)-1-azabicyclo[2.2.2]oct-2-ene or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Hexyloxypyrazinyl)-1-azabicyclo[2.2.2]octane or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Heptyloxypyrazinyl)-1-azabicyclo[2.2.2]octane or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Heptyloxypyrazinyl)-1,2,5,6-tetrahydro-1-methyl-pyridine or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Butyloxypyrazinyl)-1-azabicyclo[2.2.2]oct-2-ene or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Butyloxypyrazinyl)-1-azabicyclo[2.2.2]octane or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-(3,3,4,4,5,5,6,6,6)Nonafluorohexyloxypyrazinyl)-1-azabicyclo[2.2.2]oc t-2-ene or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Pentyloxypyrazinyl)-1-azabicyclo[2.2.2]octane or a pharmaceutically-acceptable salt thereof.
A compound which is Endo-3-(3-hexyloxypyrazinyl)-1-azabicyclo[2.2.1]heptane or a pharmaceutically-acceptable salt thereof.
A compound which is Exo-3-(3-hexyloxypyrazinyl)-1-azabicyclo[2.2.1]heptane or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Butylthiopyrazinyl)-1-azabicyclo[2.2.2]octane or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Chloropyrazinyl)-1-azabicyclo[2.2.2]octane or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Ethoxypyrazinyl)-1,2,5,6-tetrahydro-1-methylpyridine or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Propyloxypyrazinyl)-1,2,5,6-tetrahydro-1-methyl-pyridine or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Pentyloxypyrazinyl)-1,2,5,6-tetrahydro-1-methyl-pyridine or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Hexylthiopyrazinyl)-1,2,5,6-tetrahydro-1-methyl-pyridine or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Pentylthiopyrazinyl)-1,2,5,6-tetrahydro-1-methyl-pyridine or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Ethoxypyrazinyl-1-azabicyclo[2.2.2]octane or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Propyloxypyrazinyl)-1-azabicyclo[2.2.2]octane or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Pentylthiopyrazinyl)-1-azabicyclo[2.2.2]octane or a pharmaceutically-acceptable salt thereof.
A compound which is 3-(3-Hexylthiopyrazinyl)-1-azabicyclo[2.2.2]octane or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.