US 5,182,280 A · Derivatives of benzimidazole and their use as antihistamines

Abstract

The present invention relates to novel compounds derived from benzimidazole, characterized in that they correspond to the formula I, or their therapeutically acceptable salts, ##STR1## in which: R.sub.1 and R.sub.2, equal or different, represent a hydrogen atom, a halogen, a lower alkyl radical, a hydroxy radical, an alkoxy radical, an alkyl carboxylate radical, an aryl or substituted aryl radical, n may have the values 0 or 1, m may have the values 2 to 4, X, Y, Z and W, equal or different, represents a nitrogen atom or a carbon atom bonded to a hydrogen atom, a halogen or another alkyl, aryl, alkoxycarbonyl, carboxy, hydroxyl, sulfonic and alkylsulfonic radical. The present invention relates also to the treatment of various allergic disorders caused by histamine.

Claims4

Dependent claims

Compounds derived from benzimidazole characterized in that they correspond to the formula I, or their therapeutically acceptable salts, ##STR18## in which, R.sub.1 and R.sub.2, equal or different, represent a hydrogen atom, a halogen, a lower alkyl radical or a hydroxy radical,

n can have the values 0 or 1,
m can have the values 2 to 4,
X, Y, Z and W are equal or different, and represent a nitrogen atom or a carbon atom bonded to a hydrogen atom, to a halogen or to another lower alkyl, alkoxycarbonyl having up to two carbon atoms in its alkyl group, carboxy, hydroxyl or sulfo radical.

Dependencies are inferred from the claim text.

Derivatives of benzimidazole and their use as antihistamines

Life of this patent

Derivatives of benzimidazole and their use as antihistamines

Life of this patent

Abstract

Claims4